warnings/precautions: tri‐luma® cream contains sulfites which may cause severe, life-threatening allergic reactions in people allergic to sulfites. Adverse events: in the controlled clinical trials, the most frequently reported events were redness, peeling, burning, dryness, and itching at the site of application. Tri‐luma® (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) cream is indicated for the short‐term (up to 8 weeks) treatment of moderate to severe melasma of the face in the presence of measures for sun avoidance, including the use of sunscreens. If exposure cannot be avoided, sunscreen products and protective apparel should be used. Exposure to sunlight, sunlamps, or uv light and extreme heat, wind, or cold should be avoided. Avoid products that may dry or irritate the skin, such as abrasive cleansers, scrubs, or skin‐peeling agents. Reversible hpa axis (adrenal function) suppression may result from exposure to the topical corticosteroid, fluocinolone acetonide, so discontinue use if signs and symptoms of this condition occur. Safety and efficacy have not been established in individuals with darker skin. ![]() If you are pregnant, nursing or trying to become pregnant you should not use tri‐luma® cream. Tri‐luma® cream contains hydroquinone, which may cause a gradual blue‐black darkening of the skin. Tri‐luma® (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) cream is indicated for the short‐term (up to 8 weeks) treatment of moderate to severe melasma of the face in the presence of measures for sun avoidance, including the use of sunscreens. adverse events: in the controlled clinical trials, the most frequently reported events were redness, peeling, burning, dryness, and itching at the site of application. warnings/precautions: tri‐luma® cream contains sulfites which may cause severe, life‐threatening allergic reactions in people allergic to sulfites.
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